Impact of sensory experience on the construction of neural circuits
In-vivo images of an excitatory and PV+ inhibitory neuron. Upper left images are from Chattopadhyaya 2004, fixed tissue demonstrating the ‘basket’ surrounding excitatory soma formed by inhibitory axons.
Functional impact of inhibition on cortical processing
2-photon guided recording of a PV+ inhibitory neuron in an awake mouse atop a spherical treadmill. Cell-attached spike response to a drifting grating stimulus is highlighted in gray.
Sensory-motor task used to monitor structural changes in neuronal wiring during discrimination and object localization learning. Task based on O’Connor 2010.