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    Experience dependent plasticity in somatosensory cortex.

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    Network assembly and optimization using principles of neural design.

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    Experience dependent plasticity in somatosensory cortex.

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    GFP labelled population of somatostatin containing neocortical interneurons.

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    High throughput automated counting of synaptic pruning across development.

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    GABAb receptors silence excitatory synapses in the neocortex.

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    Single-whisker experience enhances response to low-intensity stimuli. © Elena Peterson

Welcome to the Barth Lab!

Research in the Barth lab is focused on understanding how experience assembles and alters the properties of neural circuits in the cerebral cortex, in both normal and disease states.

There is a postdoctoral position available in the lab.


November 2018 – The Barth lab was awarded a NIH grant to study synapses in the early stages of Alzheimer's disease.

October 2018 – Stephaie Myal was awarded the Henry L. Hillman Presidential Fellowship.

September 2018 – Nick Audette successfully defended his thesis.

May 2017 – Fluorescence synapse localization data from wild-type and Shank3 mutant mice selected for analysis by three different teams in the 2nd annual NeuroHackathon at Carnegie Mellon University. The winning team used the Shank3 dataset to find disease-related differences in synaptic morphology in cortical neurons.

March 2017 – Ajit Ray was awarded a BrainHub fellowship for collaborative projects between the Indian Institute of Science and Carnegie Mellon.

January 2017 – Dika Kuljis was awarded a training grant in the Neurobiology of Neurological Disease (T32 NS086749).

September 21, 2016 – Nick Audette was awarded the Henry L. Hillman Presidential Fellowship.

January 2016 – Joanna Urban-Ciecko was awarded the SONATA BIS from the National Science Centre, Poland.

Title: Learning-evoked plasticity of somatostatin and parvalbumin interneurons: mechanisms and impact.

December 2015 – Images from Chandrasekaran et al selected for Journal of Neuroscience December 16; 35(50): 16297-16561

September 2015 - Alison Barth named interim director of BrainHub

May 2015 – Santosh Chandrasekaran received his PhD!

Thesis Title: Unbiased, High-Throughput Electron Microscopy Analysis of Experience-Dependent Synaptic Changes.

May 2015 – Nick Audette received the Carnegie Prize in Mind and Brain Sciences Graduate Fellowship


Kuljis D.A., Zemoura K, Telmer C, Lee J, Park E, Xu W, Bruchez MP, and Barth AL Quantitative synapse analysis for cell-type specific connectomics. 2018
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Beukema P, Cecil KL, Peterson E, Mann VR, Matsushita M, Takashima Y, Navlakha S, and Barth AL TrpM8-mediated somatosensation in mouse neocortex. 2018
Urban-Ciecko J, Jouhanneau JS, Myal SE, Poulet JFA, and Barth AL. Precisely Timed Nicotinic Activation Drives SST Inhibition in Neocortical Circuits. Feb 2018
Audette NJ, Urban-Ciecko J, Matsushita M, Barth AL POm thalamocortical input drives layer-specific microcircuits in somatosensory cortex Mar 2017
Chandrasekaran S, Navlakha S, Audette NJ, McCreary DD, Suhan J, Bar-Joseph Z, and Barth AL Unbiased, high-throughput electron microscopy analysis of experience-dependent synaptic changes in the neocortex Dec 2015
More prior work →