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    Experience dependent plasticity in somatosensory cortex.

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    Network assembly and optimization using principles of neural design.

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    Network assembly and optimization using principles of neural design.

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    Development of neocortical networks for somatosenation. Click here for video.

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    Experience dependent plasticity in somatosensory cortex.

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    Activity-dependent changes in ion channel function.

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    Block-face image of TdT transgenic mouse.

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    GFP labelled population of somatostatin containing neocortical interneurons.

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    High throughput automated counting of synaptic pruning across development.

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    GABAb receptors silence excitatory synapses in the neocortex.

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    Single-whisker experience enhances response to low-intensity stimuli. © Elena Peterson

Welcome to the Barth Lab!

Research in the Barth lab is focused on understanding how experience assembles and alters the properties of neural circuits in the cerebral cortex, in both normal and disease states.

LAB NEWS

January 2016 – Joanna Urban-Ciecko is awarded the SONATA BIS from the National Science Centre, Poland.

Title: Learning-evoked plasticity of somatostatin and parvalbumin interneurons: mechanisms and impact.

December 2015 – Images from Chandrasekaran et al selected for Journal of Neuroscience December 16; 35(50): 16297-16561

September 2015 - Alison Barth named interim director of BrainHub

May 2015 – Santosh Chandrasekaran receives PhD

Thesis Title: Unbiased, High-Throughput Electron Microscopy Analysis of Experience-Dependent Synaptic Changes.

May 2015 – Nick Audette receives Carnegie Prize in Mind and Brain Sciences Graduate Fellowship

LATEST PUBLICATIONS

Chandrasekaran S, Navlakha S, Audette NJ, McCreary DD, Suhan J, Bar-Joseph Z, and Barth AL Unbiased, high-throughput electron microscopy analysis of experience-Ddpendent synaptic changes in the neocortex Dec 2015
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Pratt CP, He J, Barth AL, and Bruchez MP Fluorogenic green-inside red-outside (GIRO) labeling approach reveals adenylyl cyclase-dependent control of BKα surface expression Sep 2015
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Urban-Ciecko J, Fanselow EF, and Barth AL Neocortical somatostatin neurons reversibly silence excitatory transmission via GABAb receptors Feb 2015
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Glazewski S and Barth AL Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates Dec 2014
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More prior work →

There is a postdoctoral position available in the lab. For more information, Click Here.