About the Lab

How does Streptococcus pneumoniae (pneumococcus) colonize the human host and cause disease? This Gram-positive bacterium is a leading cause of disease and death in children and the elderly worldwide. It is a frequent colonizer of the human respiratory tract, where it asymptomatically colonizes the nasopharynx. It can also disseminate to the middle ear, lungs, brain, and heart causing local or systemic disease. Our immediate goal is to understand the pneumococcal molecules and host conditions that either promote asymptomatic colonization or trigger dissemination and disease. Our long-term objective is to identify targets for the prevention, diagnosis and treatment of bacterial disease.

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